Hormone replacement therapy (HRT) and bioidentical hormone replacement therapy (BHRT) are two approaches to supplementing hormones in both men and women. There are several key differences between these two types of treatment:
- HRT involves prescribing synthetic hormone analogues that are similar in molecular structure to hormones produced in the body. BHRT uses bioidentical hormones derived from plant sources that match the natural molecular structure of hormones made in the human body.
- HRT hormones are created in a lab to have a similar effect as human hormones. However, the chemical structure may not fully match human hormones. BHRT hormones are chemically identical to those found naturally in the body.
- The goal of both therapies is to supplement declining hormone levels, alleviating unpleasant symptoms of hormone imbalance. However, the effects and side effects may differ.
- HRT has been documented to effectively reduce symptoms like hot flashes, night sweats, and vaginal atrophy. However, some risks have also been identified over long-term use.
- Data suggests BHRT also effectively reduces menopausal symptoms when properly dosed. Little research exists on long-term safety. However, advocates argue bioidentical matches human hormones, potentially decreasing risks.
- HRT therapy is standardized in measured doses. BHRT dosing is individualized based on a person's needs through blood tests or symptom evaluation.
- In HRT, oral tablets are commonly taken once daily. BHRT may involve creams, gels or pellets to continually release hormones into the body.
- HRT treatment often consists of one type of estrogen paired with progestin. BHRT makes use of multiple natural hormones like estriol, estradiol and progesterone to better match the changing levels through a woman's menstrual cycle.
- HRT hormones have been extensively tested in large research studies assessing effectiveness and safety, allowing for informed treatment guidelines. Much lessevidence exists documenting long-term outcomes with BHRT.
In summary, while both therapies use supplemental hormones to address deficiencies,
HRT utilizes manufactured hormones that approximate natural hormones while
BHRT promises an exact structural match through the use of plant-derived bioidentical hormones.
HRT provides standardized doses informed by substantial research while
BHRT tailors doses to the individual. Ongoing research aims to clarify the safety profiles long-term.
