Xanax (alprazolam) is a commonly prescribed benzodiazepine medication used to treat anxiety and panic disorders. It works by enhancing the effects of the neurotransmitter GABA in the brain, producing a calming effect.
Testosterone is an important hormone that regulates many functions in men, including sex drive, muscle mass, bone density, and red blood cell production. So the effect of Xanax on testosterone levels is an important consideration.
Several studies have looked at the impact of benzodiazepines like Xanax on testosterone:
- An analysis of multiple studies involving over 200 men in total found that use of benzodiazepines was associated with a decrease in total and free testosterone levels in most of the studies. The decreases ranged from 8-32% reduction compared to controls.
- A 60-day study on mice also showed that chronic administration of alprazolam (Xanax) significantly reduced blood testosterone levels compared to control mice not getting the medication.
So based on the current research, it does appear that use of Xanax and related benzodiazepines
can lower testosterone production in both animal and human males.
Some key points about the effects:
- The reductions seem dose-dependent - higher doses are more likely to cause larger decreases in testosterone.
- The effects may be worse with longer-term use. The body's testosterone production may not rebound right away after stopping Xanax.
- Individual responses can vary quite a bit. Not all men taking it will experience lowered testosterone.
Potential mechanisms behind the reduction:
- Benzodiazepines like Xanax may reduce signals from the brain to the testes telling them to produce testosterone.
- They may also increase liver breakdown processes that clear testosterone from the bloodstream.
- There could also be impacts directly on the Leydig cells in the testes that produce testosterone.
The impacts of decreased testosterone can include:
In summary, Xanax and related benzos likely cause a modest but measureable
drop in testosterone in many men, especially with higher doses and longer-term usage. The effect seems to be temporary and testosterone levels often recover after the medication is stopped. But the hormonal changes may persist long enough to cause unwelcome symptoms.
Men taking these anxiety medications long-term should consider having
testing to check their hormone levels. Under doctor supervision, adjustments in dosage or adding
testosterone therapy may help counteract the effects on hormones.
The professionals at Renew Hormone Center specialize in testing and treating hormone imbalances in men and women. If you take Xanax or other medications that may impact hormones, we can help assess your levels and minimize side effects. Reach out today to learn more or set up a consultation.
